CXCL8 and keloid: Further, it has been reported that (1) exogenous IL-6 leads to scar formation of human fetal skin grafts in SCID mice42, (2) IL-8 levels are significantly increased in slowly healing human burn wounds, (3) IL-8 decreases keratinocyte differentiation in vitro43, and (4) fibroblasts from keloid scars show increased IL-8 levels compared with normal human fibroblasts44.