Cell growth inhibitory activity of S. cupulare leaf extracts; (hexane, dichloromethane, methanol, ethyl acetate, and water), as well as unannealed and annealed CdO/CdCO3 nanocomposites, was evaluated on MCF-7 (hormone receptor positive breast cancer cell line) and MDA-MB-231 (triple negative breast cancer cell line), breast cancer cell lines. This evidence concerns the gene NR4A1 and triple-negative breast carcinoma.