Confirming that the rs2431697-containing region does not operate in disease-relevant contexts in primary CD19+ B cells will be important, in light of the key role of autoreactive B-cell clones in SLE and the discrepant results in primary CD19+ B cells relative to those observed in a B-cell line (Fig. 3 a, d, e, I, m). The gene discussed is CD19; the disease is systemic lupus erythematosus.