In one patient, we detected biallelic BRCA2 deletion via targeted and WES of ctDNA (Supplementary Fig. 15b); tri-nucleotide mutational signature analysis revealed HRR-defect-associated signature 3 as one of the predominant signatures in this patient (12%; Supplementary Data 5), similar to BRCA2-deficient metastatic prostate cancer. This evidence concerns the gene BRCA2 and metastatic prostate carcinoma.