PMP22 and rheumatic heart disease: Moreover, 16 CNVs completely delete 18 genes including RHD. Complete gene deletions affect, for example, the CFHR1, CFHR3, and PMP22 genes known to predispose to hemolytic uremic syndrome and to cause Charcot–Marie–Tooth disease type 1A, Charcot–Marie–Tooth disease type 1E, Dejerine–Sottas disease, and Roussy–Levy syndrome (Table 4).