Although initially identified in brain tumors, the robustness of the signature is supported by the sustained correlation between signature genes and TERT in most cancer types from TCGA, except a few indolent types such as cholangiocarcinoma (CHOL), KICH, and pheochromocytoma and paraganglioma (PCPG). The gene discussed is TERT; the disease is hereditary pheochromocytoma-paraganglioma.