TFE3 and pancreatic insulinoma: In our CRISPR/Cas9 KO experiments, both Tfeb and Tfe3 appear to contribute to the expedited clearance of hIAPP oligomer and reduced cell death by MSL-7 because the reduction of hIAPP dimer accumulation and hIAPP-associated cell death by MSL-7 became statistically insignificant by KO of either Tfeb or Tfe3, suggesting additive effects of Tfeb and Tfe3 in the protection of insulinoma cell death by MSL-7.