Since MSL-7 induces the nuclear translocation of TFEB and TFE3, critical regulators of lysosome biogenesis and autophagy gene expression, in pancreatic islet cells or INS-1 insulinoma cells, we next studied the role of MiTF/TFE family members in the accelerated clearance of hIAPP oligomer and improved viability of islet cells. The gene discussed is MFN2; the disease is pancreatic insulinoma.