Interestingly, a significant reduction of metastatic burden was still obtained in P2rx1−/− mice and no differences of metastatic tumor growth were observed between WT and P2rx1−/− mice receiving anti-Ly6G antibodies at 4 days (Supplementary Fig. 5h), indicating that P2RX1-involved PDAC liver metastasis is neutrophils related. The gene discussed is P2RX1; the disease is neoplasm.