We found that YTHDF2 was highly expressed in GBM and mediated mRNA clearance of LXRA but did not affect the mRNA of LXRB. In fact, in the TCGA glioma dataset, the levels of YTHDF2 is inversely correlated with the levels of LXRA. Thus, the YTHDF2-mediated LXRA downregulation might explain the difference between expressions of LXRA and LXRB in GBM. The gene discussed is NR1H2; the disease is glioblastoma.