In cultured glioma tumor cell lines and normal human astrocytes, YTHDF2 protein is highly expressed in GBM cells, especially in GBM-derived stem cells (GSCs), as compared with lower-grade glioma cells (Hs683 and SW1783) and normal human astrocytes (Fig. 1g and Supplementary Fig. 1d). This evidence concerns the gene YTHDF2 and central nervous system cancer.