Finally, a correlation between YTHDF2 protein expression and the expressions of p-EGFR (Y1173), p-Src (Y419), and p-ERK1/2 in human gliomas also suggested the importance of this EGFR/SRC/ERK/YTHDF2 cascade in tumor development (Supplementary Fig. 4e, f). Here, YTHDF2 is linked to central nervous system cancer.