We first queried The Cancer Genome Atlas (TCGA)17,18, REMBRANDT19, French20, Kawaguchi21, and Paugh22 datasets, and found the expression of YTHDF2, but not YTHDF1, YTHDF3, YTHDC1, or YTHDC2 correlates with poor overall survival of glioma patients in all of the datasets (Fig. 1a–c, Supplementary Fig. 1a-b). Here, YTHDF3 is linked to central nervous system cancer.