Most importantly, adding back a shYTHDF2#1-resistant YTHDF2 to the YTHDF2-depleted GSCs rescued the malignant phenotypes of GSCs (Fig. 2d–h, Supplementary Fig. 2h-k), suggesting that YTHDF2 is important for GBM tumor growth and invasion. This evidence concerns the gene YTHDF2 and neoplasm.