Among them, the expression levels of ATOH8, C11ORF71, CELSR3, DGCR5, HIVEP2, HSPA12A, ITPK1, KIAA1755, LXRA, PCDHA1, PRDM11, PRNP, RBSN, RNF103, RWDD2A, SIRPA, SIRT3, USP54, and ZBTB47 were negative correlated (spearman correlation <−0.3) with YTHDF2 in TCGA LGG and GBM datasets (Fig. 5c, Supplementary Data 5), suggesting that these genes could be downstream effectors of YTHDF2 in glioma. The gene discussed is USP54; the disease is central nervous system cancer.