YTHDF2 and neoplasm: Moreover, when S39A/T381A mutant was expressed to a similar amount as wild-type YTHDF2 (judged by the similar mRNA levels, Supplementary Fig. 4b), it displayed minimal effects on the promotion of invasiveness of LN229 cells (Fig. 4c), proliferation of GSC11 and GSC7-2 cells (Fig. 4d, e), and tumor growth (Fig. 4f, Supplementary Fig. 4c) compared with wild-type YTHDF2.