We then examined ALDH1A3 expression in CRC cells and NCM460 cells, and found that the protein level of ALDH1A3 was higher in HCT116 and LoVo cells than in DLD1, RKO, SW480, and SW620 using Western blot (Supplementary Fig. S3e). The gene discussed is ALDH1A3; the disease is colorectal carcinoma.