EWSR1 and neoplasm: In line with EWS-FLI1 negatively regulating TAZ, an analysis of RNA expression data of 117 primary EwS tumours (GEO ID: gse3462032) revealed significant anti-correlation of TAZ expression with FLI1 (r = −0.225, p = 0.015) and with selected EWS-FLI1 activated genes (BCL11B: r = −0.539, p = 3.49e−10; NKX2–2: r = −0.448, p = 3.95e−07), as well as a positive correlation with EWS-FLI1 suppressed genes (TGFBR2: r = 0.819, p = 1.75e−29; LOX: r = 0.752, p = 0.166e−22) (Supplemental Fig. 1).