PBRM1 and nonpapillary renal cell carcinoma: However, the precise role of PBRM1 in the ccRCC immune microenvironment remains unclear, because contradictory results have shown that loss of PBRM1 reduced the binding of BRG1 to the interferon (IFN)-γ receptor 2 promoters; STAT1 phosphorylation and subsequent expression of IFN-γ target genes, therefore correlated with a nonimmunogenic phenotype60.