Among them, variants in ABCA7, ADAM10, ADAMTS1, BZRAP1-AS1, CASS4, CD2AP, CD33, CELF1, CLU, HS3ST1, and PICALM were associated with the altered gene expressions in different brain regions alone, and variants in BIN1, ECHDC3, EPHA1, HLA-DRB1, NME8, and PTK2B were associated with the altered gene expressions only in the blood, while only 6 variants in CR1, MS4A6A, SLC24A4/RIN3, and ZCWPW1 affected these 4 nearby gene expressions both in the blood and in the brain, which perhaps become promising key biomarkers for AD diagnosis. This evidence concerns the gene PICALM and Alzheimer disease.