Here, we report a comprehensive analysis of the associations of the variants in the top 30 non-APOE AD risk genes from current large-scale GWAS studies of the transcript expression levels, and the pathological processes of brain amyloidosis, tauopathy, and neurodegeneration, using the baseline and follow-up data from AD-related CSF, PET, and MRI measures. Here, APOE is linked to Alzheimer disease.