Mono-allelic PALB2 germline mutations disrupt the interaction of PALB2 with either BRCA1 or BRCA2 engender DNA damage sensitivity, HR defects, and cancer susceptibility to breast, ovarian, pancreatic whereas bi-allelic PALB2 germline mutations cause Fanconi anemia subtype FANCN, with early onset of acute myeloid leukemia, medulloblastoma, neuroblastoma and often Wilms’ tumor [12–17]. This evidence concerns the gene PALB2 and medulloblastoma.