The most recent study in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort reports that CSF t-tau and p-tau were associated with polygenic scores after correcting for APOE ε4 status, while the association seen with CSF Aβ42 was driven by APOE ε4 homozygotes [16]. The gene discussed is APOE; the disease is Alzheimer disease.