APOE and Alzheimer disease: Further, stratification of Aβ-positive and Aβ-negative individuals based on diagnostic status showed associations between the APOE PRSs, the PHS, and plasma p-tau181 in both Aβ positives and negatives in all diagnostic groups (Aβ positives: p = 5e−3–0.02, Aβ negatives: p = 1e−3–0.04) except for the AD group among Aβ positives.