Although TIMP-3 antagonizes matrix metalloproteinase activity and can suppress tumor growth, angiogenesis, invasion, and metastases [334], TIMP-3 also has other biocellular functions not related to MMP inhibition, such as the induction of apoptosis [335,336] and the inhibition of endothelial cell motility and proliferation [337]. Here, TIMP3 is linked to neoplasm.