MYC and acute myeloid leukemia: Another example of intergenic trans-acting lncRNA enhancing oncogene expression through miRNA titration, or a competing endogenous RNA (ceRNA), is CCAT1. Often upregulated in M4-M5 subtypes of AML, CCAT1 inhibits monocytic differentiation and promotes proliferation by reducing miR-155 availability and consequently increases levels of c-MYC [112].