RUNX1 and acute myeloid leukemia: HOTTIP also binds in trans with promoters of key hematopoietic regulators like PBX3, MYC, KIT, CD33, MEIS2, and RUNX1. In mice, Hottip displayed oncogenic properties leading to AML-like disease by altering the homeotic-hematopoietic gene-associated chromatin signature and transcription programs [91,101].