HOTTIP also binds in trans with promoters of key hematopoietic regulators like PBX3, MYC, KIT, CD33, MEIS2, and RUNX1. In mice, Hottip displayed oncogenic properties leading to AML-like disease by altering the homeotic-hematopoietic gene-associated chromatin signature and transcription programs [91,101]. Here, MYC is linked to acute myeloid leukemia.