ADRB2 and breast cancer: For example, chronic stress-induced epinephrine can elevate glycolytic activator lactate dehydrogenase A(LDHA) via β2-AR, leading to glucose metabolic rewiring, and the adjusted pH directed USP28-mediated deubiquitination and stabilization of MYC, activating the SLUG promoter, thereby promoting development of breast cancer stem-like properties [178].