PAK1 and lung cancer: In addition, RT induces expression of Ras related C3 botulinum toxin substrate 1 (RAC1), a member of the Rho family GTPase which promotes cell division via cell cycle [148], and enhances radioresistance via p21-activated kinase 1 (PAK1)-LIM kinase 1 (LIMK1)-Cofilins signaling in lung cancer [149].