ITGAM and neoplasm: For example, the production of CXC-motif chemokine ligand 12 (CXCL12) results in chemotaxis of pro-tumorigenic CD11b+ myeloid-derived cells, whereas the upregulation of CXCL9, CXCL10, and CXCL16 can increase the expression of adhesion molecules such as E-selectin, intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion protein 1 (VCAM-1) on endothelial cells and attract anti-tumor effector T-cells [64].