A recent study [81] demonstrated that stressed tumor bearing mice had a poorer response to radiation; conversely, an improved anti-tumor response, and increased numbers of CD8+ and CD4+ T-cells expressing IFNγ and GzmB in irradiated tumors were found in the tumors of mice treated with propranolol, suggesting that β-AR signaling on lymphocytes might be involved in hampered immunity by irradiation. Here, CD4 is linked to neoplasm.