Studies further suggested that the percentage of Th17 cells and the serum IL-6 level are dramatically elevated with aging, and the increase in Th17 T cells and IL-6 levels are correlated with CRC progression, suggesting a pro-tumorigenic role of the IL-6/Th17 T cells axis [113], an effort similar to immunosuppression mediated by IL-6. Here, IL6 is linked to colorectal carcinoma.