In addition, the expression of CXCL9, CXCL10, and CXCL11 was significantly correlated with the presence of tumor-infiltrating cytotoxic CD8+ T cells and CD4+ TH1 effector cells, which represent an independent positive predictor of prolonged disease-free survival of CRC patients [78,79]. This evidence concerns the gene CD4 and colorectal carcinoma.