A study from the CRC APCmin/+ mouse model suggested that Tregs can inhibit endothelial CXCL10 production, inhibit T cell migration in tumors, and that CXCR3 (receptor of CXCL9, CXCL10, and CXCL11)-mediated signaling is crucial for lymphocyte accumulation in intestinal tumors [80]. The gene discussed is CXCL11; the disease is colorectal carcinoma.