Another clinical study has demonstrated that the survival advantage of CRC may differ because of the different expression patterns of two groups of NKG2D ligands (MIC and RAET1G) in the tumor cells, suggesting that some expression signature of NKG2D ligands in tumor cells may inhibit the activation of NK cells and induce an immunosuppressive TME in CRC [62]. The gene discussed is KLRK1; the disease is neoplasm.