Collectively, even though these IFN-regulated CXC chemokines can evoke adaptive immunity against tumor cells, the expression reduction of these chemokines by different mechanisms (e.g., Treg-mediated repression of CXC chemokines in endothelial cells) may support an immunosuppressive microenvironment in CRC by inhibiting T cell infiltration of tumor tissues. This evidence concerns the gene IFNA1 and neoplasm.