Besides, the CD11b+CD11c+ population isolated from tumor tissues shows higher IL-6 expression compared with the same phenotypic population isolated from peripheral blood mononuclear cells (PBMCs), suggesting that T cell receptor (TCR)-mediated activation of both CD4+ T cells and CD8+ T cells was significantly reduced in these tumor tissues compared with PBMCs [68,69]. The gene discussed is CD8A; the disease is neoplasm.