Given the high prevalence of both Ni allergy and obesity in the general population and the hints coming from studies supporting a possible correlation between Ni allergy/exposure and GH-IGF1 axis disruption, we herein aimed to evaluate the relation between pituitary morphology and GH secretion in a cohort of overweight and obese subjects who were subjected to a Ni patch test for symptoms and signs suggestive of Ni-ACD/SNAS. Here, IGF1 is linked to obesity due to melanocortin 4 receptor deficiency.