YAP1 and neoplasm: Together, these results demonstrate that verteporfin and CA3 (i) inhibit TEAD transcriptional activity mainly via their ability to reduce YAP expression and thus YAP/TEAD interactions, (ii) inhibit in vitro OS cell lines viability, (iii) reduce in vivo primary tumor growth and (iv) suggest that these later effects are mainly due to their ability to induce cell apoptosis.