YAP1 and neoplasm: Our data clearly demonstrated that (1) the Hippo/YAP signature correlates with a poor survival outcome in OS patients, (2) the crucial role of TEAD in YAP-driven cell proliferation and in vivo tumor growth in OS, and (3) verteporfin and CA3, two YAP/TEAD transcriptional inhibitors, significantly reduce in vivo primary tumor growth mainly due to their ability to induce cell apoptosis.