YAP1 and neoplasm: In this context, using molecular and cellular approaches, the aims of this work were (i) to define the role of YAP in OS primary tumor growth, (ii) to elucidated the role of TEAD in YAP-driven OS tumor growth in vivo, and (iii) to evaluate the effects of two specific YAP-inhibitors, verteporfin and CA3, on the OS tumors growth using an orthotopic mouse model.