CADM1 and melanoma: In addition, long non-coding RNA lymph node metastasis associated transcript 1 (LNMAT1) epigenetically impairs the expression of CADM1 in melanoma by EZH2 recruitment, which is the key enzyme of trimethylation of histone H3 at lysine 27 (H3K27me3) and promotes hypermethylation of the CADM1 promoter, resulting in the transcriptional inhibition of CADM1 [31].