CALCA and Ecchymosis: Moreover, in newborns without infection, during the first 72 h of life, endocan serum level does not appear to be significantly influenced by sex, delivery method, the presence of meconium in the amniotic fluid, fetal bradycardia/tachycardia or presence of minor birth trauma (ecchymosis, cephalohematoma, clavicle fracture), which have been associated with elevation of CRP and PCT [107].