CRP and infection: However, in the case of neonatal population, there are multiple other pathological situations, aside from infections (bacterial or viral), associated with an increase in CRP, such as rupture of membranes (which induces an increase in CRP levels by 0.4% per hour), active labor (14.5% per hour), maternal administration of steroids (40%) or intrapartum antibiotics (28%) or chorioamnionitis without invasive fetal or neonatal disease.