CALCA and perinatal asphyxia: However, PCT, similar to CRP, was shown to be increased by several perinatal factors such as prolonged rupture of membranes ≥ 18 h, active labor, maternal administration of steroids or intrapartum antibiotics and also by non-infectious perinatal conditions including intracranial hemorrhage and hypoxic ischemic encephalopathy [16,18,68,74].