In our recent work, we studied interactions of Aβ with cypD and 17β-HSD10, and with the use of a multi-interaction model, we demonstrated that the processes associated with early stages of AD such as the oligomerization of Aβ and increased/favored production of Aβ1–42 affect the equilibrium between these biomolecules in the mitochondrial matrix [23]. This evidence concerns the gene HSD17B10 and Alzheimer disease.