Generally, increased esophageal permeability in GERD is associated with E-cadherin cleavage [33], and it was known beforehand that short-chain FAs that are also involved in the signal transduction in FFAR2 and FFAR3 [34,35] up-regulate the transcription of E-cadherin [35]. The gene discussed is FFAR3; the disease is gastroesophageal reflux disease.