(12) POU5F1 (OCT4), SOX2, NANOG activates genes related to proliferation (REACT_264617).POU5F1 (OCT4), SOX2, and NANOG bind elements in the promoters of the target gene playing a role in developmental biology, OCT4 regulatory networks in embryonic stem cells, and embryonal carcinoma cells [40]. Here, POU5F1 is linked to embryonal carcinoma.