ALB and neoplasm: Covalent BSH prodrugs utilizing such linkages to either EB/analogs thereof, or to serum albumin directly, would be expected to release the vast majority of their short-lived cytotoxic payload only after these macromolecular complexes were confined to the tumor intracellular spaces, since this half-life is much greater than the half-life for EPR sequestration (~15 h) of the macromolecular prodrug.