NFE2L2 encodes NRF2 and NRF2 has proved to be activated in neurons and glial cells, but mainly in astrocytes, in patients with Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis [128]. The gene discussed is NFE2L2; the disease is amyotrophic lateral sclerosis.