In contrast, Myr (300 mg/kg) treatment reciprocated TGF-β1 (p < 0.01), P-Smad3 (p < 0.01), Smad7 (p < 0.05), and collagen IV (p < 0.05) expressions in the kidneys of T2D rats (Figure 12g,h). This evidence concerns the gene SMAD3 and type 2 diabetes mellitus.