KEAP1 and type 2 diabetes mellitus: In addition, T2D caused suppression of Nrf-2 signaling of endogenous redox defense in the renal cells evidenced by a ⁓0.6-fold (p < 0.01) reduction in P-Nrf-2 expression in the nucleus and ⁓2.6-fold (p < 0.01) activation of Keap1 expression in the cytosol (Figure 12e,f).