In cancer cells, DLEU1 (lncRNA deleted in lymphocytic leukemia 1) could serve as an oncogenic lncRNA that promotes hepatocellular carcinoma tumorigenesis by acting as a ceRNA to regulate the expression of IGF-1R and its downstream PI3K/AKT signaling pathway genes by directly sponging miR-133a [68]. This evidence concerns the gene IGF1R and cancer.