Considering the glucagon-stimulating effects of GIP at low but not high plasma glucose levels [262], the results by Schirra et al. [264] suggest that this may be a mechanism to protect from postprandial hypoglycemia (transient rebound of glucose levels), a frequent finding after the ingestion of high glycemic index/load nutrients, due to postprandial hyperinsulinemia. The gene discussed is GCG; the disease is Hyperinsulinemia.