The findings on the permissive role of Ankrd2 in spheroid formation (Figure 5B) and in the modulation of MMP2 and MMP9 activities (Figure 6), as well as the evidence that Ankrd2-depleted clones lose the ability to form spheroids (Figure 7C), hint at a positive role for Ankrd2 in triggering metastases and tumor spreading. This evidence concerns the gene MMP2 and neoplasm.