ANKRD2 and cancer: Moreover, since in C2C12 myoblasts most of the cellular functions of Ankrd2 are mediated by its phosphorylation on S99 by Akt2 [10,11], and since Akt2 plays a key role in the progression of several types of cancer including OS [20], we were also interested in determining if S99 might be involved in oncogenesis of OS.