As published evidence has reported that Ankrd2 is also expressed in tumor cells, such as human esophageal carcinoma [2] and rhabdomyosarcoma [3,16], and since osteoblasts and myocytes are mesenchymal-derived cells strongly susceptible to mechanical stress, in order to discover new therapeutic targets, the main object of this study was to evaluate the role of Ankrd2 in the patho-physiology of OS. The gene discussed is ANKRD2; the disease is rhabdomyosarcoma.