INS and pancreatic insulinoma: Brambillasca et al. showed that Cdkal1 silencing in rat insulinoma cells not only affects insulin but also reduces the expression of chromogranin A and islet cell autoantigen 512, which are present in insulin secretory granules [112] suggesting that the activity of this ER-localized tRNA-modifying enzyme is needed for efficient translation of certain secretory proteins [112].