Taking into account the proportion of CD8+ CD38+ cells in the three studied groups, we noticed the highest percentage and GMF intensity of CD38 in COVID-19(+) patients, while due to the lack of statistical differences between COVID-19(+) patients and the COVID-19(−) virus group, the CD8+ CD38+ cell analysis did not separate COVID-19(+) patients on this basis. This evidence concerns the gene CD38 and COVID-19.