Various Drosophila models of ALS targeting SOD1 [18], FUS [19], VAMP-associated protein B (VAPB) [20], TDP-43 [21], Valosin-containing protein (VCP)/p97 [22], Ubiquilin-2 (UBQLN2) [23], C9orf72 [24], and some of their Drosophila homologues have been established and analyzed [8]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.