MALAT1 and amyotrophic lateral sclerosis: Furthermore, TDP-43 and FUS may be involved in regulating the expression of lncRNAs such as NEAT1 and MALAT1. The depletion of TDP-43 or FUS upregulated both NEAT1 and MALAT1 lncRNAs in mouse ALS/FTD models (Table 2) [65,66].