In cell lines SW-480 and SW-620 over-expression of miR-130b downregulates integrin β1, leading to the impaired migration and invasion of CRC cells [36] whereas another analysis of a series of CRC cell lines showed that miR-130b acts as an efficient inducer of EMT in vivo and in vitro, likely through up-regulation of Snail and ZEB1 transcription factors. The gene discussed is SNAI1; the disease is colorectal carcinoma.