PRNP and head and neck squamous cell carcinoma: Interestingly, a specific analysis of PRNP gene mutations using the Cancer Genome Atlas (TCGA) database revealed a total of 48 somatic mutations in the PRNP gene in different cancers, encompassing lung adenocarcinoma, colorectal adenocarcinoma, endometrial carcinoma, head and neck squamous cell carcinoma, and melanoma [130].