Tumor-derived IL-6 and CSF-1 affect DC differentiation, promoting lineage commitment toward suppressive monocytes [114] and VEGF inhibits DC maturation by suppressing NFκB signaling in hematopoietic progenitors [115] as well as the tumor-derived TGF-β can inhibit antigen uptake [116]. The gene discussed is TGFB1; the disease is neoplasm.