CCNC and neoplasm: Pretreatment of the model cervical cancer HeLa cells with a stapled peptide mimetic (S-HAD) that disrupts the interaction between the highly conserved tumor suppressor cyclin C, a transcriptional regulator canonically found in the nucleus, and the Mediator, a transcriptional coactivator complex of RNA polymerase II, led to effective sensitization of these cells to cisplatin treatment [87].