Despite the mitochondrial fission-promoting response of cyclin C to H2O2 or S-HAD could be recapitulated in murine poorly differentiated thyroid cancer (PDTC) cell line, this effect may be uncoupled from Bax activation as there was no difference observed between the numbers of apoptotic cells in the control and CCNC siRNA cells following cisplatin treatment. The gene discussed is CCNC; the disease is thyroid gland carcinoma.