Baicalein also inhibited NLRP3 inflammasome activation by decreasing the expression of NLRP3, caspase-1, and IL-1β, the activation of NF-κB by suppressing NF-κB phosphorylation, and the levels of ROS in pristine-induced lupus mice and LPS-stimulated MDSCs [83]. The gene discussed is NFKB1; the disease is systemic lupus erythematosus.