No variants matching our filtering criteria were detected in any known genes associated with Noonan syndrome, other RASopathies (PTPN11, SOS1, RAF1, RIT1, KRAS, NRAS, BRAF, SHOC2, CBL, MEK1, MEK2, HRAS, MAP2K1, MAP2K2, NF1), or other genes associated with CHARGE syndrome (SEMA3E). This evidence concerns the gene MAP2K2 and RASopathy.