No variants matching our filtering criteria were detected in any known genes associated with Noonan syndrome, other RASopathies (PTPN11, SOS1, RAF1, RIT1, KRAS, NRAS, BRAF, SHOC2, CBL, MEK1, MEK2, HRAS, MAP2K1, MAP2K2, NF1), or other genes associated with CHARGE syndrome (SEMA3E). Here, SHOC2 is linked to RASopathy.