To develop a treatment for acromegaly, an endocrine disorder characterized by an increased secretion of pituitary growth hormone (GH), Somm et al. made a modified fusion construct of the GH-releasing hormone with the translocation domain of HCD and the LCD, which cleaves one of the protein of the SNARE complex responsible for GH secretion, VAMP2 [50]. The gene discussed is GH1; the disease is acromegaly.