CRP and neoplasm: World Health Organization Performance Status (WHO PS) ≥ 1, tumor stage IV, the presence of active brain metastases (symptomatic or requiring corticosteroids for symptom control), ≥2 metastatic sites, ≥1 prior therapies, ALB < LLN (lower limit of normal), LDH ≥ ULN, CRP ≥ 2ULN, ALC < 750/mm3, ANC ≥ 7500/mm3, and a neutrophil-to-lymphocyte ratio (NLR) ≥ 5 were associated with worse PFS in univariate analysis (p ≤ 0.042) (Table 3).