In univariate analysis, WHO PS ≥1, tumor stage IV, the presence of active brain metastases, ≥2 metastatic sites, ≥1 prior therapies, corticosteroid use (≥8 mg of methylprednisolone, or equivalent), ALB < LLN, CRP ≥ 2ULN, LDH ≥ ULN, ALC < 750/mm3, ANC ≥ 7500/mm3, and an NLR ≥5 were associated with worse OS (p ≤ 0.013) (Table 3). Here, CRP is linked to neoplasm.