In univariate analysis, WHO PS ≥ 1, tumor stage IV, the presence of active brain metastases, ≥2 metastatic sites, ≥1 prior therapies, ALB < LLN, LDH ≥ ULN, CRP ≥ 2ULN, ALC < 750/mm3, and NLR ≥ 5 were associated with worse PFS (p ≤ 0.039). The gene discussed is CRP; the disease is neoplasm.