WHO PS ≥ 1, tumor stage IV, the presence of active brain metastases, ≥2 metastatic sites, baseline corticosteroid use, ALB < LLN, LDH ≥ ULN, CRP ≥ 2ULN, ALC < 750/mm3, NLR ≥ 5, and TMTV ≥ 80 mL were significantly associated with worse PFS and OS in univariate analysis (p ≤ 0.047) (Table 4). Here, CRP is linked to neoplasm.