ADSL and infection: For example, hCAP18/LL37, one of the best-characterized peptides in skin defense, is upregulated in the epidermis as a result of skin injury and infection, while mice deficient in the murine homolog of hCAP18/LL37 (CRAMP) are more susceptible to serious cutaneous streptococcal infections [74], highlighting the importance of AMPs in skin protection against bacteria.