IL27RA and endometrial cancer: Another important aspect of IL-27 in regulating the NK cell response against uterine endometrial cancer cell (UECC) was recently reported by Zhou et al. In this study, the production of IL-27 by uterine endometrial cancer cells in the presence of rapamycin upregulated the expression of WSX-1 and gp130 on NK cells and increased their cytotoxic activity against cancer cells in a xenograft mouse model [135].