Moreover, IL-12 facilitates antigen presentation by upregulating MHCI on tumor cells, favoring polarization to M1 macrophages and attracting effector immune cells by enhancing the production of the chemokines CXCL9, CXCL10 and CXCL11 [5,14,15,16]. This evidence concerns the gene CXCL9 and neoplasm.