HuR-NP treatment significantly diminished protein expression of HuR, Cyclin D1, Cyclin E1, BCL-2, HIF1-α, VEGEF-A, and an increased expression of p27 at both 24 h and 48 h in melanoma cell lines (Figure 2 and Figure S3; p < 0.05). This evidence concerns the gene BCL2 and melanoma.