In the AT of obese individuals, plasma concentrations of myeloperoxidase (MPO) and calprotectin (a factor mainly derived from neutrophils) as well as the levels of neutrophil activation marker CD66b were found to be increased compared with lean controls, suggesting that obesity also affects systemic activation of neutrophils [114]. The gene discussed is MPO; the disease is obesity due to melanocortin 4 receptor deficiency.