Chu et al. [192] synthesized several PROTAC molecules that recognize the tau protein, one of them called TH006, which binds the VHL E3 ligase effectively (Von Hippel–Lindau protein functioning in human cells as E3 ubiquitin ligase), causing poly-ubiquitination and tau degradation in neuroblastoma cells and lowering tau levels in a mouse AD model. This evidence concerns the gene MAPT and Alzheimer disease.