Exogenous addition of GM3 to HCT116 colon cancer cells have an anti-proliferative effect by stimulating cyclin-dependent kinase inhibitor (CDKI) p21 (WAF1) through the inhibition of the PI3K/AKT/MDM2 survival signaling pathway [80] (Figure 4). The gene discussed is CDKN1A; the disease is malignant colon neoplasm.