For instance, knockdown of Gb3S (encoded by A4GALT), using siRNA in colon cancer epithelial cells [46] or Shiga toxin in patient-derived gastric adenocarcinomas [52], decreased the cells’ capacity to migrate and proliferate in vitro and in vivo compared to cells with impaired Gb3 expression [52]. Here, A4GALT is linked to colonic neoplasm.