To investigate the impact of VPREB1 gene editing on myeloma cell line, the 4,5-dimethylthiazol -2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was conducted on treated and untreated cells in order to assess the effect of inhibition on cell proliferation and growth. This evidence concerns the gene VPREB1 and plasma cell myeloma.